RECRUITINGINTERVENTIONAL

Mode of Exercise and Bone Biomarkers in Older Veterans

Anabolic Versus Catabolic Skeletal Effects of Endurance or Resistance Exercise in Older Veterans

About This Trial

Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.

Who May Be Eligible (Plain English)

Who May Qualify: - Healthy older (60+ y) Veteran women and men in the Denver Metro Area - Normally active (e.g., recreational cycling or walking exercise) Who Should NOT Join This Trial: - Impaired renal function, defined as an eGRF of \<60 mL/min/1.73m2 - Hepatobiliary disease, defined as liver function tests (AST, ALT) \>1.5 times the upper limit of normal - Thyroid dysfunction, defined as an ultrasensitive thyroid stimulating hormone (TSH) \<0.5 or \>5.0 mU/L - Serum Ca \<8.5 or \>10.3 mg/dL - Serum 25(OH)D \<20 ng/mL - Uncontrolled hypertension, defined as resting systolic blood pressure (BP) \>150 mmHg or diastolic BP \>90 mmHg; - History of type 1 or type 2 diabetes - Cardiovascular disease, defined as subjective or objective indicators of ischemic heart disease (e.g., angina, ST segment depression) or serious arrhythmias at rest or during the graded exercise test (GXT). Volunteers who have a positive GXT can be re-considered after follow-up evaluation, which must include diagnostic testing (e.g., stress echocardiogram or thallium stress test) with interpretation by a cardiologist - Anemia, defined as a serum hemoglobin \<12.1 g/dL for women and \<14.3 g/dL for men - Fracture in the past 6 months - Current diagnosis or symptoms of COVID-19 In the event of abnormal BP, live function, TSH, 25(OH)D, or hemoglobin values, volunteers can be reassessed, including after appropriate follow-up evaluation and treatment by a primary care provider. Those who have experienced symptoms of COVID-19 or have been formally diagnosed will be allowed to participate once symptoms have resolved and they are approved to return to exercise by their primary care provider. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Healthy older (60+ y) Veteran women and men in the Denver Metro Area * Normally active (e.g., recreational cycling or walking exercise) Exclusion Criteria: * Impaired renal function, defined as an eGRF of \<60 mL/min/1.73m2 * Hepatobiliary disease, defined as liver function tests (AST, ALT) \>1.5 times the upper limit of normal * Thyroid dysfunction, defined as an ultrasensitive thyroid stimulating hormone (TSH) \<0.5 or \>5.0 mU/L * Serum Ca \<8.5 or \>10.3 mg/dL * Serum 25(OH)D \<20 ng/mL * Uncontrolled hypertension, defined as resting systolic blood pressure (BP) \>150 mmHg or diastolic BP \>90 mmHg; * History of type 1 or type 2 diabetes * Cardiovascular disease, defined as subjective or objective indicators of ischemic heart disease (e.g., angina, ST segment depression) or serious arrhythmias at rest or during the graded exercise test (GXT). Volunteers who have a positive GXT can be re-considered after follow-up evaluation, which must include diagnostic testing (e.g., stress echocardiogram or thallium stress test) with interpretation by a cardiologist * Anemia, defined as a serum hemoglobin \<12.1 g/dL for women and \<14.3 g/dL for men * Fracture in the past 6 months * Current diagnosis or symptoms of COVID-19 In the event of abnormal BP, live function, TSH, 25(OH)D, or hemoglobin values, volunteers can be reassessed, including after appropriate follow-up evaluation and treatment by a primary care provider. Those who have experienced symptoms of COVID-19 or have been formally diagnosed will be allowed to participate once symptoms have resolved and they are approved to return to exercise by their primary care provider.

Treatments Being Tested

BEHAVIORAL

10 Weeks of Supervised Resistance Exercise Training

Participants will be randomized to complete 10 weeks of either resistance (weight lifting, hopping) supervised exercise. Exercise will be 3x per week for 1 hour each session. There are a total of 30 exercise sessions.

BEHAVIORAL

10 Weeks of Supervised Endurance Exercise Training

Participants will be randomized to complete 10 weeks of endurance (stationary cycling) supervised exercise. Exercise will be 3x per week for 1 hour each session. There are a total of 30 exercise sessions.

Locations (1)

Rocky Mountain Regional VA Medical Center, Aurora, CO

Aurora, Colorado, United States