RECRUITINGINTERVENTIONAL
The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR)
The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR):4 Randomized Crossover Studies
About This Trial
The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD. Regarding secondary objective, the investigators hypothesize that BFR results in lower blood pressure responses compared to traditional exercise training in both healthy and COPD participants.
Who May Be Eligible (Plain English)
Inclusion and exclusion for the healthy participants are defined by the following criteria.
Who May Qualify:
- Age ≥ 18 years
- Clinically healthy
Who Should NOT Join This Trial:
- Physical or intellectual impairment precluding willing to sign a consent form or protocol adherence
- Non-German speaking (precluding willing to sign a consent form)
- Pain during exercise of any origin
- Pregnancy
- History of thromboembolic event in the lower extremity
- Resting systolic blood pressure \<100 mmHg
Inclusion and exclusion for the COPD participants are defined by the following criteria.
Who May Qualify:
- Age ≥ 18 years
- Diagnosed COPD according to GOLD-guidelines12
Who Should NOT Join This Trial:
- Physical or intellectual impairment precluding willing to sign a consent form or protocol adherence
- Non-German speaking (precluding willing to sign a consent form)
- Acute or recent (within the last 6 weeks) exacerbation of COPD
- Pain during exercise of any origin
- Pregnancy
- History of thromboembolic event in the lower extremity
- Resting systolic blood pressure \<100 mmHg
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion and exclusion for the healthy participants are defined by the following criteria.
Inclusion criteria:
* Age ≥ 18 years
* Clinically healthy
Exclusion criteria:
* Physical or intellectual impairment precluding informed consent or protocol adherence
* Non-German speaking (precluding informed consent)
* Pain during exercise of any origin
* Pregnancy
* History of thromboembolic event in the lower extremity
* Resting systolic blood pressure \<100 mmHg
Inclusion and exclusion for the COPD participants are defined by the following criteria.
Inclusion criteria:
* Age ≥ 18 years
* Diagnosed COPD according to GOLD-guidelines12
Exclusion criteria:
* Physical or intellectual impairment precluding informed consent or protocol adherence
* Non-German speaking (precluding informed consent)
* Acute or recent (within the last 6 weeks) exacerbation of COPD
* Pain during exercise of any origin
* Pregnancy
* History of thromboembolic event in the lower extremity
* Resting systolic blood pressure \<100 mmHg
Treatments Being Tested
OTHER
Blod flow restriction training
includes one strength and one endurance training
Locations (1)
University Hospital Zürich
Zurich, Switzerland