Longitudinal Oral Microbiome Sampling for BE

Who May Qualify: - Scheduled for an upper endoscopy or had upper endoscopy within past three years - Eighteen years of age or older - Capable of producing a saliva sample - Able to give willing to sign a consent form - For BE patients only: Endoscopic evidence of Barrett's esophagus (at least 1 cm maximal BE length; i.e. Prague classification: any C, M≥1), and intestinal metaplasia present on esophageal biopsies Who Should NOT Join This Trial: - History of head and neck cancer or esophageal squamous cell or gastric cancer - History of esophageal or gastric surgery - Scheduled to undergo colonoscopy on the day of initial saliva collection - Scheduled only for Endoscopic retrograde cholangiopancreatography (ERCP) or Endoscopy ultrasound (EUS) without accompanying standard upper endoscopy on the day of initial saliva collection - For BE patients only: History of prior endoscopic therapy for BE except a history of prior Endoscopic mucosal resection (EMR) of focal lesions without subsequent ablative therapy is permitted Always talk to your doctor about whether this trial is right for you.