Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk

Who May Qualify: - Patient over 18 years old, and less than 85 years old. - Patient with positive AAN (AAN ≥ 1/160) with the following specificity: anti-Scl70 or anti-centromere or anti-RNApolIII, or any other auto-antibodies related to systemic sclerosis - Patient with RP reported by the subject and confirmed by the physician. - Patient affiliated to a health insurance system. - Patient who accepts to participate to the study and signs an inform consent form. Who Should NOT Join This Trial: - Patient with an SSc diagnosis according to ACR/EULAR 2013 criteria. - Patient with skin fibrosis at screening. - Patient with antiplatelet treatment at screening. - Patient with contraindications to clopidogrel. - Patient treated by immunosuppressive agent at screening. - Patient treated by anticoagulants at screening - Pregnant or breastfeeding women. - Women of childbearing age refusing effective contraception method during the study treatment (24 months). - Incompetent adults (i.e. Individuals under the protection of a conservator) Always talk to your doctor about whether this trial is right for you.