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RECRUITINGINTERVENTIONAL

Amygdala Memory Enhancement

Mechanisms of Amygdala-Mediated Memory Enhancement in Humans

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

Who May Be Eligible (Plain English)

Who May Qualify: - Must be able to understand and speak English. - Able to provide willing to sign a consent form. - Diagnosed with epilepsy. - Scheduled to undergo long-term intra-cranial video monitoring for seizure onset localization. - Must be implanted with intracranial depth electrodes to the left or right amygdala, hippocampus, and parahippocampal/perirhinal cortices. Who Should NOT Join This Trial: - Unable to understand and speak English. - Unable to provide willing to sign a consent form. - Not diagnosed with epilepsy. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Must be able to understand and speak English. * Able to provide informed consent. * Diagnosed with epilepsy. * Scheduled to undergo long-term intra-cranial video monitoring for seizure onset localization. * Must be implanted with intracranial depth electrodes to the left or right amygdala, hippocampus, and parahippocampal/perirhinal cortices. Exclusion Criteria: * Unable to understand and speak English. * Unable to provide informed consent. * Not diagnosed with epilepsy.

Treatments Being Tested

DEVICE

Intracranial Stimulation

Electrodes localized to the BLA will be stimulated with either active-BLAES (0.5-3.5 mA, theta-modulated gamma burst) electrical stimulation for a 1-sec duration immediately following item image presentation or sham-BLAES (zero-amplitude). At later stages of the project, stimulation parameters and timing will be varied and triggered not at random, but by real-time closed-loop analysis of memory biomarkers in the medial temporal lobe.

Locations (1)

Washington University School of Medicine
St Louis, Missouri, United States