Hemoperfusion in Critical Patients With Septic Multiorgan Dysfunction Syndrome.

Who May Qualify: - Patients with a sepsis diagnosis, according to the diagnostic criteria of the International Sepsis-3 Consensus Conference, and without response to the treatment of septic shock who meet the following conditions: - Sepsis of abdominal origin with controlled infectious focus. - Noradrenaline dose\> 0.5 µg / kg / min to maintain adequate organ perfusion after optimization of fluid therapy. - Dysfunction of two or more organs with SOFA ≥ 9 (5). - Blood lactate ≥ 2 mmol / L. - Procalcitonin (PCT)\> 10 ng / mL. - CRP\> 100 mg / L. - IL-6\> 2000 pg / ml. Who Should NOT Join This Trial: - Age under 18 years or over 80 years. - Pregnancy or breastfeeding. - Terminally ill patients or with a life expectancy of less than 48 hours. - Thrombocytopenia \<60,000 / mm3. - Pancytopenia. - Severe coagulopathy with high risk of bleeding. - Inclusion in another research protocol. - In case of re-entry during the study period, only the first admission will be included. - Use of another haemoperfusion device. Always talk to your doctor about whether this trial is right for you.