Biomarker Development for Muscular Dystrophies

Who May Qualify: - Subjects with DM1 or DM2 based on genetic testing and/or clinical criteria (some subjects who have positive genetic testing may be asymptomatic, while other subjects who show characteristic clinical features may have declined to have genetic testing done). Control non-DM subjects are unknown to have DM or any other muscular dystrophy by history and may have had no genetic testing. - Able to provide willing to sign a consent form or assent for participation in the study. - Demographic characteristics for single biofluid collection: Males and females age 5 years and older. - Demographic characteristics for serial biofluid and muscle function testing: Males and females age 14 years and older with DM1. - Demographic characteristics for biofluid and muscle biopsy: Males and females, ages 18-65 years. Demographic characteristics for single biofluid collection, ultrasound, and myography: Males and females age 14 years and older. Who Should NOT Join This Trial: - Medical history of any of the following. State of immunosuppression; coagulopathy; pre-existing liver or kidney disease; documented HIV positive; documented hepatitis B and/or C positive. - Medications and other drugs. Use of anti-platelet drugs within 7 days prior to blood draw or biopsy; use of anticoagulants within 60 days prior to blood draw or biopsy; active drug or alcohol use or dependence that, in the opinion of the biopsy surgeon, would interfere with post-procedure wound care. - Other. Inability or unwillingness of the subject to give written willing to sign a consent form. Always talk to your doctor about whether this trial is right for you.