Effectiveness of an Immediate Postoperative Intravesical Instillation With Either Gemcitabine or Epirubicin in Patients With Urinary Bladder Cancer (Gemcitabine Epirubicin Normal SAline)

Who May Qualify: - Primary urinary bladder tumor - Secondary urinary bladder tumor (recurrence) - Bipolar or monopolar resection - Creat \<2.2mg/dl - 35% \<Hct \<52% - White bloode cells count WBC ≥3000 / μL - 75000 \<PLT \<500000 / μL - Urine culture: negative / sterile - Alkaline phosphatase, total bilirubin, SGOT, SGPT: values as high as 2 times above the upper normal limit - Good clinical condition (according to Eastern Cooperative Oncology Group PS ≤ 1) - CT Urography without findings suggesting an upper urinary tract tumor in the last 3 months before the transurethral resection of the bladder tumor Who Should NOT Join This Trial: - More than 2 low grade / high differentiation (low grade / LG) diagnosed by tissue sample (biopsy-confirmed) bladder tumors in the last 18 months before the transurethral resection of the bladder tumor - High grade / low differentiation (HG) diagnosed by tissue sample (biopsy-confirmed) bladder tumor in the last 9 months before the transurethral resection of the bladder tumor - Those who undergo a transurethral resection of a bladder tumor according to the Guidelines of the European Association of Urology for non-muscle-invasive bladder cancer: incomplete resection of tumor, absence of muscle fibers in the sample with the exception of: Ta / LG-G1, primary Cis and finally, pT1 tumors - Intravesical instillation of chemotherapeutic agent or BCG in the last 6 months before the transurethral resection of the bladder tumor - History of non-urothelial bladder cancer - Stage of disease pT2 (muscle-invasive bladder cancer) - Presence of a tumor in the urethra - Upper urinary tract malignancy (present or anamnestically) - History of pelvic radiotherapy - Histrory of another malignancy in the last 5 years before the transurethral resection of the bladder tumor Always talk to your doctor about whether this trial is right for you.