RECRUITINGOBSERVATIONAL
Treating Hepatitis C in Pakistan. Strategies to Avoid Resistance to Antiviral Drugs
About This Trial
We will determine how best to manage the hepatitis C virus (HCV) epidemic in Pakistan by measuring effectiveness of Pakistan-government sponsored current therapies, emergence of viral resistance, consequences of infection (chiefly liver cancer) and through developing models, based on incidence data, determine the proportion of people who need curative treatment to eliminate HCV, and assess whether targeting can optimise this.
Who May Be Eligible (Plain English)
Who May Qualify:
- Adults over 18yrs old
- Willing to undergo hepatitis C testing
- Able and willing to give willing to sign a consent form
- Willing to return in 12 months time for repeat testing
- Resident in area and not planning to leave the region
Who Should NOT Join This Trial:
- Unwilling to give consent
- Unwilling or unable to undergo the necessary procedures
- Clinically significant illness (other than HCV) or other major medical condition that may interfere with the subject's treatment, assessment or compliance with protocol.
- Co-morbidities limiting life expectancy to less than 12 months
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Adults over 18yrs old
* Willing to undergo hepatitis C testing
* Able and willing to give informed consent
* Willing to return in 12 months time for repeat testing
* Resident in area and not planning to leave the region
Exclusion Criteria:
* Unwilling to give consent
* Unwilling or unable to undergo the necessary procedures
* Clinically significant illness (other than HCV) or other major medical condition that may interfere with the subject's treatment, assessment or compliance with protocol.
* Co-morbidities limiting life expectancy to less than 12 months
Treatments Being Tested
DIAGNOSTIC_TEST
HCV RNA (PCR)
We will test HCV positive patients after treatment to observe if they achieve SVR
DIAGNOSTIC_TEST
HCV Antibody test (Point of care)
HCV antibody test used to establish if patients have had or are actively infected with HCV
DIAGNOSTIC_TEST
AST/ALT and platelets measurement
AST/ALT and platelets to determine APRI score
Locations (1)
Aga Khan University
Karachi, Pakistan