High Dose Omeprazole in Patients With Pancreatic Cancer

Who May Qualify: - Newly diagnosed exocrine pancreatic cancer with either pathology, histology, or radiology imaging documented as adenocarcinoma - Patient is a candidate for surgical resection of pancreatic cancer - ≥ 18 years old at the time of willing to sign a consent form - You should be able to carry out daily activities with 0 level of ability (ECOG 0)-2 - Patients with or without neoadjuvant chemotherapy will be eligible - Ability to provide written willing to sign a consent form and HIPAA authorization - Women of childbearing potential definition must have a negative pregnancy test within 14 days of registration. All women (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) are considered to have childbearing potential unless they meet one of the following criteria: - Prior hysterectomy or bilateral oophorectomy; - Has not had menses at any time in the preceding 24 consecutive months - Candidate for surgery per standard of care of per surgeon's discretion Who Should NOT Join This Trial: - Patients with pancreatic malignant tumor diagnosed by tissue sample (biopsy-confirmed) as neuroendocrine or any other type of malignancies - Positive pregnancy test, pregnant, or breastfeeding - Known hypersensitivity to any component of the formulation or substituted benzimidazoles - Any other clinically significant laboratory abnormality that would compromise patient safety or the outcome of the study - Any clinically significant and/or uncontrolled cardiac-related abnormality that would compromise patient safety or the outcome of the study - Medical condition that might affect the absorption of study medications in the opinion of the investigator. Always talk to your doctor about whether this trial is right for you.