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RECRUITINGINTERVENTIONAL

Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Older adults with coronary artery disease (CAD) have impaired vascular and inspiratory muscle function. The objective of this study is to examine the effect of beet juice supplementation on vascular and inspiratory muscle function in older adults with CAD.

Who May Be Eligible (Plain English)

Who May Qualify: - Adults with coronary artery disease (CAD) based on an angiogram \>50% stenosis in any major epicardial vessel or history of myocardial infarction or history of coronary revascularization. - Considered to have stable CAD on optimal medical therapy - 60 to 85 years of age - Men and women (women must be postmenopausal either natural or surgical) - Able to give consent Who Should NOT Join This Trial: - Ejection fraction \<50%, unstable angina, recent myocardial infarction within 6 months - Coronary revascularization, including percutaneous coronary intervention and coronary artery bypass graft or thoracic surgery within 6 months. - Stroke, obstructive pulmonary disease, hepatitis B, C, HIV, seizures, or other relevant on-going or recurrent illness - Individuals that have participated in respiratory training within the last 12 months or cardiac rehabilitation within the last 6 months - Uncontrolled hypertension - Use of tobacco products including smoking traditional or e-cigarettes - Use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone) - Regular aerobic exercise training - Unwilling to stop using mouthwash at least 1 week before the start of the study and during study participation - Unwilling to remain weight stable during study participation Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Adults with coronary artery disease (CAD) based on an angiogram \>50% stenosis in any major epicardial vessel or history of myocardial infarction or history of coronary revascularization. * Considered to have stable CAD on optimal medical therapy * 60 to 85 years of age * Men and women (women must be postmenopausal either natural or surgical) * Able to give consent Exclusion Criteria: * Ejection fraction \<50%, unstable angina, recent myocardial infarction within 6 months * Coronary revascularization, including percutaneous coronary intervention and coronary artery bypass graft or thoracic surgery within 6 months. * Stroke, obstructive pulmonary disease, hepatitis B, C, HIV, seizures, or other relevant on-going or recurrent illness * Individuals that have participated in respiratory training within the last 12 months or cardiac rehabilitation within the last 6 months * Uncontrolled hypertension * Use of tobacco products including smoking traditional or e-cigarettes * Use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone) * Regular aerobic exercise training * Unwilling to stop using mouthwash at least 1 week before the start of the study and during study participation * Unwilling to remain weight stable during study participation

Treatments Being Tested

DIETARY_SUPPLEMENT

Nitrate rich beetroot juice

Participants will drink nitrate rich beetroot juice (2.4 floz ; Beet It Sport Nitrate 400 concentrated beetroot shot; James White Drink, ltd) twice daily for two weeks.

DIETARY_SUPPLEMENT

Nitrate depleted beetroot juice

Participants will drink nitrate depleted beetroot juice (2.4 floz ; Beet It placebo concentrated beetroot shot; James White Drink, ltd) twice daily for two weeks.

Locations (1)

Integrative Cardiovascular Physiology Laboratory, University of Florida
Gainesville, Florida, United States