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RECRUITINGINTERVENTIONAL

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Who May Be Eligible (Plain English)

Who May Qualify: - Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center - Planned clinical electrode trajectory that contacts caudate - Age greater than or equal to 40 - Diagnosis of Parkinson's disease - Able to participate in intraoperative testing - English speaking Who Should NOT Join This Trial: - Age less than 40 - Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions) - Movement disorder other than Parkinson's disease Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion criteria: * Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center * Planned clinical electrode trajectory that contacts caudate * Age greater than or equal to 40 * Diagnosis of Parkinson's disease * Able to participate in intraoperative testing * English speaking Exclusion criteria: * Age less than 40 * Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions) * Movement disorder other than Parkinson's disease

Treatments Being Tested

OTHER

Neurophysiology recordings

Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated

OTHER

Neural stimulation

Neural stimulation will be delivered during a gambling task and its impact on task performance quantified

Locations (1)

Vanderbilt University Medical Center
Nashville, Tennessee, United States