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RECRUITINGINTERVENTIONAL

Function Integrity of Neck Anatomy in Thyroid Surgery

Preserving Function Integrity of Neck Anatomy in Thyroid Surgery: A Randomized Clinical Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Recent trends in the management of patients with low-risk papillary thyroid carcinoma who have a nonsuspicious or cytologically benign contralateral nodule call into question the need for routine total thyroidectomy. Although the lobectomy for the unilateral thyroid cancer with contralateral benign nodules is sufficient treatment, some of the patients might suffer from the anxiety of the residual benign thyroid nodule and tend to choose total thyroidectomy, which might be overtreatment. Thermal ablation has been proven to be effective in achieving nodule shrinkage and being also free from major complications. In our institution, intraoperative RFA was a proposed alternative strategy to treat the contralateral benign nodules after the thyroid lobectomy for the malignant lobe, which was found to have a better quality of life on anxiety, physiological health, social family, psychological and sensory mentions with a considerable complication rate.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients diagnosed with unilateral thyroid carcinoma and contralateral benign nodule confirmed by preoperative ultrasound-guided fine-needle aspiration cytology; - Patients with contralateral nodules ≤ 20mm and located in the thyroid gland; - Patients with clinical node-negative cervical compartment at palpation and neck ultrasound. Who Should NOT Join This Trial: - Previous history of neck surgery - Previous history of neck radiation therapy Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients diagnosed with unilateral thyroid carcinoma and contralateral benign nodule confirmed by preoperative ultrasound-guided fine-needle aspiration cytology; * Patients with contralateral nodules ≤ 20mm and located in the thyroid gland; * Patients with clinical node-negative cervical compartment at palpation and neck ultrasound. Exclusion Criteria: * Previous history of neck surgery * Previous history of neck radiation therapy

Treatments Being Tested

PROCEDURE

Intraoperative thermal ablation

After the thyroid lobectomy, the contralateral benign thyroid nodule was treated with intraoperative thermal ablation. The "hydrodissection technique'' was used during the ablation process to prevent recurrent laryngeal nerve, esophageal and other important structures from being destroyed by heat energy.

Locations (1)

Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China