Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Who May Qualify: Healthy Volunteers: - Subject has no diagnosed pulmonary conditions - Ability to read and understand English or Spanish Subjects with Lung Disease: - Subject has a diagnosis of pulmonary dysfunction made by a physician - No acute worsening of pulmonary function in the past 30 days - Ability to read and understand English or Spanish Who Should NOT Join This Trial: - MRI is contraindicated based on responses to MRI screening questionnaire - Subject is pregnant or lactating - Subject does not fit into 129Xe vest coil used for MRI - Subject cannot hold his/her breath for 15-16 seconds - Subject deemed unlikely to be able to comply with instructions during imaging - Oxygen saturation \<88% on room air or with supplemental oxygen - Cognitive deficits that preclude ability to provide consent - Institutionalization Always talk to your doctor about whether this trial is right for you.