Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis
About This Trial
The aim of this study is to investigate the effect of strict blood pressure control versus conventional care in patients with asymptomatic moderate to severe aortic valve stenosis. The study is a randomized (1:1), open label, controlled intervention trial. Hypothesis: 1. Strict BP control for 12 months reduces the progression of LV remodelling compared to conventional treatment. 2. Strict BP control for 2 years reduces the increase in aortic valve calcification and LV remodelling compared to conventional treatment. 3. Strict BP reduction for up to 10 years reduces the need for aortic valve replacement and cardiovascular events compared to conventional care.
Who May Be Eligible (Plain English)
Original Eligibility Criteria
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Treatments Being Tested
Blood presssure reduction
Patients will be uptitrated in antihypertensive treatment until the treatment target is achieved.