RECRUITINGINTERVENTIONAL
Sleep Spindles and Memory in Rolandic Epilepsy
Auditory Stimulation Effect on Spindles and Sleep Dependent Learning in Rolandic Epilepsy
About This Trial
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.
Who May Be Eligible (Plain English)
Who May Qualify:
1. Ages 4-18 years
2. Diagnosed with childhood epilepsy with centrotemporal spikes (CECTS) or Rolandic epilepsy by child neurologist
3. Has EEG with sleep activated centrotemporal spikes
4. Has had at least 1 focal motor or generalized seizure
Who Should NOT Join This Trial:
1. Has abnormal brain MRI
2. Has other unrelated neurological disease
3. Unable to have an MRI/MEG
1. Claustrophobic
2. History of frequent vomiting
3. Permanent metal in body, braces
4. Over MRI weight limit: 350lbs
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
1. Ages 4-18 years
2. Diagnosed with childhood epilepsy with centrotemporal spikes (CECTS) or Rolandic epilepsy by child neurologist
3. Has EEG with sleep activated centrotemporal spikes
4. Has had at least 1 focal motor or generalized seizure
Exclusion Criteria:
1. Has abnormal brain MRI
2. Has other unrelated neurological disease
3. Unable to have an MRI/MEG
1. Claustrophobic
2. History of frequent vomiting
3. Permanent metal in body, braces
4. Over MRI weight limit: 350lbs
Treatments Being Tested
OTHER
Auditory stimulation
Quiet auditory stimulation timed with sleep physiology
Locations (1)
Athinoula A. Martinos Center Biomedical Imaging
Charlestown, Massachusetts, United States