RECRUITINGOBSERVATIONAL

Sarcopenia, Fall and Osteoporosis in Chronic Kidney Disease

Sarcopenia, Fall and Osteoporosis in Patients With Chronic Kidney Disease

About This Trial

This study is a cross-sectional study that wishes to investigate whether there is an increased incidence of sarcopenia in patients with chronic kidney disease compared to the Danish background population. A possible association between sarcopenia and fall, as well as the incidence of osteoporosis in patients with chronic kidney disease will also be described.

Who May Be Eligible (Plain English)

Who May Qualify: - Age ≥20 years - Chronic kidney disease stage 4-5 not on dialysis (nonD) (corresponding to an estimated glomerular filtration rate (eGFR) ≤30 ml/min based on Kidney Disease Improving Global Outcomes (KDIGO) definition and not on dialysis) Who Should NOT Join This Trial: - Kidney transplanted - Immobilized/hospitalized for more than 1 week within the last 6 weeks - Active treatment with growth hormone or sex hormone - Known muscle disease - The lack of ability to speak or understand Danish - The lack of ability to give an willing to sign a consent form - The lack of ability to participate in a clinical study based on the assessment by the local investigator Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Age ≥20 years * Chronic kidney disease stage 4-5 not on dialysis (nonD) (corresponding to an estimated glomerular filtration rate (eGFR) ≤30 ml/min based on Kidney Disease Improving Global Outcomes (KDIGO) definition and not on dialysis) Exclusion Criteria: * Kidney transplanted * Immobilized/hospitalized for more than 1 week within the last 6 weeks * Active treatment with growth hormone or sex hormone * Known muscle disease * The lack of ability to speak or understand Danish * The lack of ability to give an informed consent * The lack of ability to participate in a clinical study based on the assessment by the local investigator

Treatments Being Tested

DIAGNOSTIC_TEST

DXA

Each participant will undergo one DXA scan

OTHER

Muscle strength and function assessment

Each patient will have their muscle strength and function assessed with the measurements of handgrip strength, 10 m gait speed and a 30 s sit-to-stand test. They will also fill out a questionnaire assessing Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls (SARC-F questionnaire).

OTHER

Blood samples

Each patient will undergo a physical examination and also deliver blood samples.

Locations (2)

Herlev and Gentofte Hospital, Herlev Hospital

Herlev, Denmark

Odense University Hospital

Odense, Denmark