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RECRUITINGINTERVENTIONAL

Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

Impact of Decreased Venous Return on Supine Blood Pressure

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective at lowering supine blood pressure, these approaches may be utilized to treat supine hypertension non-pharmacologically. Raising the head of the bed decreases the amount of blood returning to the heart due to the effects of gravity. In this case, the decreased blood return to the heart may decrease blood pressure.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients with autonomic failure and with supine hypertension from all races - Males and females, between 18 to 85 years Who Should NOT Join This Trial: - All medical students - Pregnant women - High-risk patients (for example: heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction) - History of serious allergies or asthma. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients with autonomic failure and with supine hypertension from all races * Males and females, between 18 to 85 years Exclusion Criteria: * All medical students * Pregnant women * High-risk patients (for example: heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction) * History of serious allergies or asthma.

Treatments Being Tested

OTHER

Tilt

Tilt of the whole bed so that the head is elevated by 9 and/or 12 inches in an acute trial or overnight.

OTHER

Elevated trunk

Elevation of the trunk through raising just the head of the bed until the head is elevated by 9 and/or 12 inches in an acute trial or overnight.

OTHER

Tilt - In home

Tilt of the whole bed so that the head is elevated by 8 inches overnight.

OTHER

Elevated Trunk - In home

Elevation of the trunk through raising the head 8 inches on a wedge pillow overnight.

Locations (1)

Vanderbilt University Medical Center
Nashville, Tennessee, United States