Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

Who May Qualify: - People with prostates ≥40 years of age - Documented germline pathogenic variant in known or suspected genes associated with prostate cancer risk. Who Should NOT Join This Trial: - Prior diagnosis of prostate cancer - Medical contraindication to any of the study procedures (e.g., prostate biopsy) - For all cancer types except non-melanoma skin cancer, any cancer treatment with curative intent within the past 12 months (e.g., surgery, radiation, chemotherapy, immunotherapy) - Prior or concurrent participation in an interventional clinical trial aimed at preventing cancer for people with germline variants associated with increased prostate cancer risk - Unable to provide written willing to sign a consent form - Unable or unwilling to complete clinical care and study procedures as indicated by the study protocol. Always talk to your doctor about whether this trial is right for you.