Skip to main content
TrialFinder
TrialFinder is for informational purposes only and does not provide medical advice. Always talk to your doctor about whether a trial is right for you.
RECRUITINGOBSERVATIONAL

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).

Who May Be Eligible (Plain English)

Who May Qualify: CXL Group - Age 8-35 years - Clinical diagnosis of keratoconus and seeking CXL treatment - English speaking ability sufficient to comprehend consent with parental assistance - MRI compatible - Ability to lie still for an MRI session (60 minutes) Control Group - Age 8-35 years - No diagnosis of keratoconus - English speaking ability sufficient to comprehend consent with parental assistance - MRI compatible - Ability to lie still for an MRI session (60 minutes) Exclusion Criteria (Both Groups): - Claustrophobic - Weight \> 285 lbs (weight limit of the MRI table) - Significant medical history, including: Current DSM-IV-TR axis I psychiatric disorders. Chronic pain Significant head injury Seizures Brain tumor Cerebrovascular accident Neurological disease aside from migraine HIV-AIDs Prescription medication strongly implicated in causing dry eyes - Magnetic implants or metal-containing tattoos on their chest or above - Pregnancy - History of contact lens wear - Any allergic response to a numbing eyedrop in the past Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: CXL Group * Age 8-35 years * Clinical diagnosis of keratoconus and seeking CXL treatment * English speaking ability sufficient to comprehend consent with parental assistance * MRI compatible * Ability to lie still for an MRI session (60 minutes) Control Group * Age 8-35 years * No diagnosis of keratoconus * English speaking ability sufficient to comprehend consent with parental assistance * MRI compatible * Ability to lie still for an MRI session (60 minutes) Exclusion Criteria (Both Groups): * Claustrophobic * Weight \> 285 lbs (weight limit of the MRI table) * Significant medical history, including: Current DSM-IV-TR axis I psychiatric disorders. Chronic pain Significant head injury Seizures Brain tumor Cerebrovascular accident Neurological disease aside from migraine HIV-AIDs Prescription medication strongly implicated in causing dry eyes * Magnetic implants or metal-containing tattoos on their chest or above * Pregnancy * History of contact lens wear * Any allergic response to a numbing eyedrop in the past

Locations (1)

Boston Children's Hospital
Boston, Massachusetts, United States