Optimization of NIBS for Treatment of Addiction

Inclusion Criteria Participants must meet all of the following: - Provide willing to sign a consent form - Age 18-85 years - Diagnosis of opioid use disorder (DSM-5) with ongoing non-prescription opioid use confirmed by self-report and urine toxicology - Report current opioid craving - Enrolled in a certified Opioid Treatment Program and receiving methadone maintenance treatment - Stable methadone dose prior to enrollment - Reside locally with no plans to relocate during the study Exclusion Criteria Participants will be excluded if they: - Are pregnant - Have frequent illicit stimulant use or acute stimulant intoxication - Are using substances or medications that may interfere with study assessments (e.g., stimulant medications, buprenorphine-based therapies, naltrexone) - Have significant neurological conditions (e.g., stroke, epilepsy, brain tumor), abnormal EEG findings, history of brain surgery, significant head injury, or unexplained syncope - Have contraindications to noninvasive brain stimulation (e.g., metal in the head, implanted brain devices) - Have moderate to severe depression or active suicidal ideation/behavior - Have active malignancy - Consume substances that could confound opioid toxicology results (e.g., poppy-seed products) Always talk to your doctor about whether this trial is right for you.