RECRUITINGINTERVENTIONAL
The Olmsted NAFLD Epidemiology Study (TONES)
About This Trial
Researchers are assessing the prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) in the population and assembling a well-characterized cohort of adults with NAFLD and NASH to validate models of NAFLD diagnosis and determine long-term outcomes.
Who May Be Eligible (Plain English)
Who May Qualify:
- Olmsted County residents at the time of search
- Age 18 or older
- No personal history of NAFLD diagnosis (administrative codes)
Who Should NOT Join This Trial:
- Alcohol in excess (more than 20 gm per week in women and 30 gm per week in men)
- Currently pregnant
- Have contraindications to MRI (MRI incompatible implanted devices, severe claustrophobia)
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Olmsted County residents at the time of search
* Age 18 or older
* No personal history of NAFLD diagnosis (administrative codes)
Exclusion Criteria:
* Alcohol in excess (more than 20 gm per week in women and 30 gm per week in men)
* Currently pregnant
* Have contraindications to MRI (MRI incompatible implanted devices, severe claustrophobia)
Treatments Being Tested
DIAGNOSTIC_TEST
Magnetic Resonance Elastography
Combines MRI imaging with sound waves to create a visual map (elastogram) showing the stiffness of body tissues.
OTHER
Blood draw
Clinical blood tests with a focus on liver function parameters and diabetes
PROCEDURE
Liver biopsy
If indicated per MRE results a biopsy will be taken of the liver.
PROCEDURE
Fibro Scan
If indicated per MRE results a fibroscan will be performed of the liver.
Locations (1)
Mayo Clinic in Rochester
Rochester, Minnesota, United States