RECRUITINGOBSERVATIONAL
Characterization of Vaginal, Urinary and Fecal Microbiomes in Women with Recurrent Urinary Tract Infections
About This Trial
The objectives are to evaluate whether variations in vaginal and/or urinary and/or fecal microbiome predispose postmenopausal women to recurrent cystitis. This will be explored using comparison of microbiome profiles between those with recurrent UTI compared to age-matched women without recurrent UTI.
Who May Be Eligible (Plain English)
Patients' Who May Qualify:
- Menopausal status
- Two or more documented, culture-positive infections in the last six months or ≥3 infections in the last year Patients' exclusion criteria
- Neurogenic bladder condition
- Known immunodeficiencies
- Usage of antibiotics or probiotics within the previous month
- Known renal calculi or anatomic malformations
Control subjects- Who May Qualify:
- Menopausal status
- Sterile urine cultures, normal urinalysis, and negative sexually-transmitted PCR urine assay
Control subjects- Who Should NOT Join This Trial:
\- A prior history of UTIs or other urologic abnormalities.
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Patients' inclusion criteria:
* Menopausal status
* Two or more documented, culture-positive infections in the last six months or ≥3 infections in the last year Patients' exclusion criteria
* Neurogenic bladder condition
* Known immunodeficiencies
* Usage of antibiotics or probiotics within the previous month
* Known renal calculi or anatomic malformations
Control subjects- Inclusion criteria:
* Menopausal status
* Sterile urine cultures, normal urinalysis, and negative sexually-transmitted PCR urine assay
Control subjects- Exclusion criteria:
\- A prior history of UTIs or other urologic abnormalities.
Locations (1)
Hadassah Medical Center
Jerusalem, Jerusalem, Israel