RECRUITINGOBSERVATIONAL
Pathogenic Study of Adult Immune Enteropathies
About This Trial
The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.
Who May Be Eligible (Plain English)
Who May Qualify:
- 18 years or over
- affiliated to social insurance
- signed willing to sign a consent form
Who Should NOT Join This Trial:
- pregnancy
- under guardianship
- not able to sign willing to sign a consent form
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* 18 years or over
* affiliated to social insurance
* signed informed consent
Exclusion Criteria:
* pregnancy
* under guardianship
* not able to sign informed consent
Treatments Being Tested
GENETIC
Blood sample collection; gastrointestinal biopsy
Targeted Next generation sequencing and whole exome sequencing Phenotyping of intestinal lymphocytes, single cell analyses, cytokines dosage...
Locations (4)
Hôpital Henri Mondor
Créteil, France
Hôpital Bicêtre
Le Kremlin-Bicêtre, France
Hôpital Saint Louis
Paris, France
Hôpital Cochin
Paris, France