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RECRUITINGOBSERVATIONAL

Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

In this research study we want to learn more about the characteristics of neutrophils that are present in the blood and secretions from a breathing tube of patients with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell that are part of the body's immune system. Even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in the lungs in patients with sepsis. Neutrophils can change their character in sepsis. Because of this, it is important for doctors to know what kind of neutrophils are in the blood and secretions from the breathing tube of patients with sepsis so that they can work to develop therapies to prevent these cells from being harmful.

Who May Be Eligible (Plain English)

Case Who May Qualify: - sepsis patient in the ICU with a breathing tube Control Who May Qualify: - scheduled for an elective surgical procedure and need preoperative blood draw or will have an intravenous catheter placed for the purpose of their surgical procedure - Plan to have endotracheal tube for planned procedures. Who Should NOT Join This Trial: - On chronic immunosuppressive drugs such as chronic corticosteroid use, or preexisting weakened immune system diseases (oncology patients, patients with transplantation) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Case Inclusion Criteria: * sepsis patient in the ICU with a breathing tube Control Inclusion Criteria: * scheduled for an elective surgical procedure and need preoperative blood draw or will have an intravenous catheter placed for the purpose of their surgical procedure * Plan to have endotracheal tube for planned procedures. Exclusion Criteria: * On chronic immunosuppressive drugs such as chronic corticosteroid use, or preexisting immunodeficiency diseases (oncology patients, patients with transplantation)

Treatments Being Tested

OTHER

Sepsis

Sepsis patients in the ICU with a breathing tube

Locations (1)

Boston Children's Hospital
Boston, Massachusetts, United States