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RECRUITINGOBSERVATIONAL

Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)

UK GCA Consortium: Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

A multi-centre observational study recruiting prospective and retrospective cohorts of patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The primary aim is to find genetic determinants of GCA and PMR susceptibility, in order to yield novel insights into disease pathogenesis. A subset of the retrospective cohort is also enrolled in a post-marketing surveillance registry of patients eligible for, or receiving tocilizumab, to treat their relapsing or refractory GCA.

Who May Be Eligible (Plain English)

Who May Qualify: - Willing to self-identify an ethnic group, such as Caucasian, Asian, Afro-Caribbean. - Have a firm clinical diagnosis of GCA or PMR, or (for patients identified prospectively) GCA or PMR should be more likely than any alternative explanation for the patient's symptoms. - Able and willing to give willing to sign a consent form. Patients will be 50 years of age or over, unless both biopsy-proven and a clinically classical case of GCA. Who Should NOT Join This Trial: • Patient unwilling or unable to give fully willing to sign a consent form. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Willing to self-identify an ethnic group, such as Caucasian, Asian, Afro-Caribbean. * Have a firm clinical diagnosis of GCA or PMR, or (for patients identified prospectively) GCA or PMR should be more likely than any alternative explanation for the patient's symptoms. * Able and willing to give informed consent. Patients will be 50 years of age or over, unless both biopsy-proven and a clinically classical case of GCA. Exclusion Criteria: • Patient unwilling or unable to give fully informed consent.

Locations (20)

Queen Elizabeth The Queen Mother Hospital
Canterbury, Kent, United Kingdom
Whiston Hospital
Prescot, Merseyside, United Kingdom
Nevill Hall Hospital, Aneurin Bevan University Health Board
Abergavenny, United Kingdom
Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust
Aylesbury, United Kingdom
Betsi Cadwaladr University Health Board
Bangor, United Kingdom
Barnsley Hospital, Barnsley Hospital NHS Foundation Trust
Barnsley, United Kingdom
Basildon University Hospital, Basildon and Thurrock University Hospitals NHS Foundation Trust
Basildon, United Kingdom
Basingstoke and North Hampshire Hospital, Hampshire Hospitals NHS Foundation Trust
Basingstoke, United Kingdom
Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Bath NHS Foundation Trust
Bath, United Kingdom
Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust
Bristol, United Kingdom
Queen's Hospital, University Hospitals of Derby and Burton NHS Foundation Trust
Burton-on-Trent, United Kingdom
West Suffolk Hospital, West Suffolk NHS Foundation Trust
Bury St Edmunds, United Kingdom
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
Chelsea and Westminster Hospital, Chelsea and Westminster Hospital NHS Foundation Trust
Chelsea, United Kingdom
West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust
Chelsea, United Kingdom
Ashford and St Peter's Hospitals, Ashford & St Peter's Hospitals NHS Foundation Trust
Chertsey, United Kingdom
Countess of Chester Hospital, Countess of Chester NHS Foundation Trust
Chester, United Kingdom
Christchurch Hospital, University Hospitals Dorset NHS Foundation Trust
Christchurch, United Kingdom