Alternative Prophylaxis in Female Recurrent Urinary Tract Infections

Who May Qualify: - Documented history of rUTI, defined as ≥ 3 episodes of (un)complicated UTI documented by urine culture with the isolation of ≥103 cfu/ml of an identified pathogen in the last year with clinical symptoms OR 2 episodes in the last 6 month Who Should NOT Join This Trial: - No willing to sign a consent form - Concomitant UTI (\< 7 days prior to randomisation) - Ongoing antimicrobial prophylaxis (e.g. for rUTI or for any other reason like endocarditis, transplanted patients under immunosuppression) - Ongoing prophylactic strategy (e.g. immunoactive prophylaxis) - Documented underlying urogenital abnormality (e.g. significant post voiding residual volume (\>50 ml), urethral stricture, urethral diverticula, urinary stone, reflux, urinary neoplasia), urological device (e.g. catheter, ureteral stent) or symptomatic pelvic floor disorder (e.g. genital prolapse stage ≥ II) - Concomitant disease (i.e. renal insufficiency, diabetes mellitus, corticosteroid use) - Urogenital urological or gynecological surgery \< 6 weeks - Known allergy to the study medication - Use of spermicides or intrauterine device - Pregnancy Always talk to your doctor about whether this trial is right for you.