PET Imaging of Inflammation and Lipid Lowering Study

Who May Qualify: - Male or female participants \>18 years old - Able to give written, willing to sign a consent form and to lie flat - Have primary hypercholesterolaemia (non-familial or definite or possible heterozygous familial hypercholesterolaemia (HeFH) based on clinical criteria) or mixed dyslipidaemia, and - History of CVD (acute coronary syndrome, coronary or other revascularisation procedures, coronary heart disease, ischaemic stroke, or peripheral arterial disease) and elevated LDL cholesterol ≥2.6 despite maximum tolerated statins with or without other lipid lowering therapies (see NICE TA 733), and - Lipid lowering therapy unchanged for at least 6 weeks prior to screening, and - Pre-existing carotid atherosclerotic plaque ≥15mm by B-mode ultrasound Who Should NOT Join This Trial: - Women of childbearing potential not using adequate contraception - Contra-indication to MRI scanning - Statin-associated myositis or liver function abnormality - Already taking inclisiran or colchicine - Sensitivity and/or contraindication to inclisiran or colchicine. Contraindications to colchicine include severe hepatic or renal impairment, blood disorders, and patients with renal or hepatic impairment who are taking a P-gp inhibitor or a strong CYP3A4 inhibitor - Contrast allergy or contrast-nephropathy - Chronic kidney disease (eGFR \<30 mL/min/1.73 m2) - Cardiovascular event within 6 months - Any medical condition, in the opinion of the investigator, that prevents the participant from lying flat during scanning, or from participating in the study - Uncontrolled chronic inflammatory disorder - History of recent malignancy deemed relevant to the study by the investigator - Treatment with medications that result in significant drug to drug interactions with the study medications - Current use of systemic corticosteroids or other immunosuppressive drugs - Previous or planned carotid endarterectomy surgery or stenting on the index side Always talk to your doctor about whether this trial is right for you.