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RECRUITINGINTERVENTIONAL

QuantiFERON-CMV Test in a Prediction for Colic Cytomegalovirus Reactivation During Ulcerative Colitis

Place of the QuantiFERON-CMV (QF-CMV) Test in a Prediction for Colic Cytomegalovirus Reactivation During Ulcerative Colitis (UC)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

CytoMegaloVirus (CMV) infection impairs evolution of Ulcerative Colitis (UC) leading to more severe and resistant to immunosuppressive therapies flare-up. CytoMegaloVirus (CMV) reactivation is assessed by the quantification of the CytoMegaloVirus (CMV) DeoxyriboNucleic Acid (DNA) load by real-time PCR (qPCR) in colonic biopsies; this assay is invasive and costly. The QuantiFERON-CytoMegaloVirus (QF-CMV) assay measures the immune response against CytoMegaloVirus (CMV) in a blood specimen.

Who May Be Eligible (Plain English)

Who May Qualify: - Patient with seropositive for CytoMegaloVirus (CMV) (IgG+) - Patient requiring hospitalization for flare of Ulcerative Colitis (UC) with Mayo score \> 5 and an endoscopic subscore ≥ 2 - Social security affiliation - Signed willing to sign a consent form Who Should NOT Join This Trial: - Wardship patient and curatorial patient - Patient unable to understand or sign the protocol - Colectomy total or partial Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patient with seropositive for CytoMegaloVirus (CMV) (IgG+) * Patient requiring hospitalization for flare of Ulcerative Colitis (UC) with Mayo score \> 5 and an endoscopic subscore ≥ 2 * Social security affiliation * Signed informed consent Exclusion Criteria: * Wardship patient and curatorial patient * Patient unable to understand or sign the protocol * Colectomy total or partial

Treatments Being Tested

PROCEDURE

Biopsies

Two more biopsies in inflammatory zone will be collected.

BIOLOGICAL

Blood samples

Blood samples will be performed necessary at QuantiFERON-CMV (QF-CMV) test.

Locations (2)

HCL-Hôpital Lyon Sud
Lyon, France
Chu Saint-Etienne
Saint-Etienne, France