A Pancreatic Cancer Screening Study in Individuals With New-Onset or Deteriorating Diabetes Mellitus

Who May Qualify: - Age of at least 50 years. - DM of Confirmed Duration: DM diagnosed within the past 12 months AND documentation of prior normal FPG, OGTT or HbA1c levels within the past 2 years. Requirement for HbA1c ≥ 6.5% OR - DM of Unconfirmed Duration: DM diagnosed within the past 12 months BUT no prior record of normal FPG, HbA1c or OGTT within the past 2 years. Requirement for HbA1c ≥ 7.0% OR - Transition from pre-Diabetes to Diabetes Mellitus within the past 12 months characterized by a change in the HbA1c of ≥ 0.5% OR - DM With Only One FDR: DM diagnosed within the past 12 months that is of Confirmed or Unconfirmed Duration, in an individual with 1 FDR. Requirement for HbA1c ≥ 6.5%. OR - Deteriorating Diabetes: DM with \>2% spike in HbA1c within past 6 months confirmed with repeat testing and NOT associated with weight gain and diabetes medication non-compliance - You should be able to carry out daily activities with 0 level of ability (ECOG 0)-1. - No known contraindications to MRI examination or gadolinium contrast. - Willing to undergo MRI and screening for metal implants or metal injury. - Recent BUN and Cr - Estimated GFR (eGFR) must be greater than 30 mL/min. - Ability to provide willing to sign a consent form. - Willing to return to study site for all study assessments. Who Should NOT Join This Trial: - Prior history of pancreatic cancer. - Presence of metastatic cancer or cancer requiring adjuvant chemotherapy within the past 5 years. - Received chemotherapy within the past 6 months. (Hormonal therapy is allowable if the disease free interval is at least 5 years). - Hereditary pancreatitis. - eGFR \< 30 mL/min. - Contraindication to MRI examination or gadolinium contrast. - Pregnant or nursing women. - Co-morbid illnesses or other concurrent disease which, in the judgment of the clinicians obtaining willing to sign a consent form, would make the participant inappropriate for entry into this study. Always talk to your doctor about whether this trial is right for you.