RECRUITINGINTERVENTIONAL

Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention

Change of Adipose Tissues and Triglyceride in Obese Patients With Non-alcoholic Fatty Liver Disease After Bariatric Surgery or Life-style Intervention

About This Trial

The study is aimed * To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery. * To test the hypothesis that Brown fat is an independent biomarker for the development of Non Alcoholic Fat Liver Disease (NAFLD) * To study the association among Brown fat, NAFLD and obesity.

Who May Be Eligible (Plain English)

Who May Qualify: - BMI ≥ 25-30 kg/m2 - BMI ≥ 30 kg/m2 with Metabolic syndrome - BMI ≥ 35 kg/m2 for morbid obesity Who Should NOT Join This Trial: - Other kind of hepatic diseases - Under medications known to affect liver fat - Waist circumference ≥ 150 cm - Weight ≥ 250 kg - MRI contraindications Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * BMI ≥ 25-30 kg/m2 * BMI ≥ 30 kg/m2 with Metabolic syndrome * BMI ≥ 35 kg/m2 for morbid obesity Exclusion Criteria: * Other kind of hepatic diseases * Under medications known to affect liver fat * Waist circumference ≥ 150 cm * Weight ≥ 250 kg * MRI contraindications

Treatments Being Tested

PROCEDURE

Bariatric surgery

Use of the normal bariatric surgery procedures commonly conducted in our hospital, such as: Laparoscopic Roux-en-Y gastric bypass (RYGB) and Laparoscopic sleeve gastrectomy (LSG)

BEHAVIORAL

Dietitian led life style modification intervention

Intensive 6 months life style changes supervised by diatitians.

BEHAVIORAL

Conventional care (control)

receive routine care

Locations (1)

The Chinese University of Hong Kong, Prince of Wale Hospital

Hong Kong, Shatin, Hong Kong