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RECRUITINGINTERVENTIONAL

Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information. Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group. Primary purpose: To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group. Secondary purposes: * to study the evolution over time of memory consolidation * to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture

Who May Be Eligible (Plain English)

Who May Qualify: Principal: - normal psychomotor development - willing to sign a consent form signed by both parents and subject if able - affiliated to social security regimen Specific Patients from "severe" and "benign" groups: - focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria) - children hospitalized for their follow-up - normal neuroimaging Control group -children hospitalized for a non neurologic disease Who Should NOT Join This Trial: Principal: Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French language Minor under care Specific Patients from "severe" and "benign" groups: - degenerative disease - abnormal neuroimaging - mental deficiency Control group - neurologic trouble - abnormal sleep EEG - intellectual deficiency Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: Principal: * normal psychomotor development * informed consent signed by both parents and subject if able * affiliated to social security regimen Specific Patients from "severe" and "benign" groups: * focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria) * children hospitalized for their follow-up * normal neuroimaging Control group -children hospitalized for a non neurologic disease Exclusion Criteria: Principal: Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French language Minor under care Specific Patients from "severe" and "benign" groups: * degenerative disease * abnormal neuroimaging * mental deficiency Control group * neurologic trouble * abnormal sleep EEG * intellectual deficiency

Treatments Being Tested

BEHAVIORAL

Neuropsychological testing

memory, executive testing, behaviour questionnaire, visual attention,

BEHAVIORAL

Neuropsychological procedure

Rey auditory verbal learning test, Delayed recall : 1h, 5h, 24h (after one night sleep)

OTHER

Video EEG and polysomnography

Video EEG : 10 electrodes + 3 electrodes for PSG 2h wake EEG Whole night EEG

Locations (2)

Hopital D'Enfants Pediatrie Medicale Ambulatoire
Nancy, France
Hopital de Hautepierre-Service de Pediatrie/Neurologie
Strasbourg, France