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RECRUITINGINTERVENTIONAL

Collagen Cross-linking in Keratoconus

Clinical Trial of Laser Custom Corneal Collagen Cross-Linking in Keratoconus

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.

Who May Be Eligible (Plain English)

Who May Qualify: - Diagnosis of keratoconus - Minimum corneal thickness of 410 microns Who Should NOT Join This Trial: - Inability to maintain fixation for OCT imaging - Inability to commit to required study visits - Inability to give willing to sign a consent form - Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery - Mature cataracts if found to limit visual potential to worse than 20/40 Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Diagnosis of keratoconus * Minimum corneal thickness of 410 microns Exclusion Criteria: * Inability to maintain fixation for OCT imaging * Inability to commit to required study visits * Inability to give informed consent * Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery * Mature cataracts if found to limit visual potential to worse than 20/40

Treatments Being Tested

PROCEDURE

Laser Custom Corneal Collagen Cross-Linking

Preoperative measurements from the OCT are used to assist the calculation in deciding the laser depth settings for smoothing the anterior corneal surface and removing any present opacities. The surgeon uses the OCT data to plan treatment parameters while preserving at least 360 microns of residual corneal stroma using a phototherapeutic keratectomy procedure. After the laser procedure, adjunctive MMC or saline solution will be applied to the cornea in accordance with the group to which the treated eye is randomized. The CXL procedure is then performed following the FDA-approved CXL regimen by Avedro, Inc.

Locations (1)

Oregon Health & Science University
Portland, Oregon, United States