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RECRUITINGOBSERVATIONAL

Genetics Of Autoimmunity In Type I Diabetes

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The purpose of this study is to gain more information about the step-by-step process that causes someone to develop type 1 diabetes. Scientists think that a person's own immune system, directed by genetic and environmental factors play a major role in its development. Participation involves a blood draw, a brief medical history questionnaire and measurements of height and weight. Some participants will be asked to return for annual follow-up visits for 10 years.

Who May Be Eligible (Plain English)

Inclusion Criteria (Families): - Families where at least one first-degree family member has type 1 diabetes - The diabetic proband in the family was diagnosed before the age of 39 - Family members must be at least 2 years old to participate Exclusion Criteria (Families): - Families with no history of type 1 diabetes - Families with a history of diabetes that is not type 1 (LADA, MODY, type 2 etc.) Inclusion Criteria (Controls): - No family history of type 1 diabetes or other autoimmune conditions - Age 2 or older Exclusion Criteria (Controls): - Personal or family history of autoimmune conditions (where your immune system attacks your own body) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria (Families): * Families where at least one first-degree family member has type 1 diabetes * The diabetic proband in the family was diagnosed before the age of 39 * Family members must be at least 2 years old to participate Exclusion Criteria (Families): * Families with no history of type 1 diabetes * Families with a history of diabetes that is not type 1 (LADA, MODY, type 2 etc.) Inclusion Criteria (Controls): * No family history of type 1 diabetes or other autoimmune conditions * Age 2 or older Exclusion Criteria (Controls): * Personal or family history of autoimmune disease

Treatments Being Tested

OTHER

Blood Collection

Blood will be collected via venipuncture and analyzed. Blood samples will be analyzed for HLA haplotype (a genetic sequence related to type 1 diabetes susceptibility), plasma-induced signature, diabetes autoantibodies, complete blood count with differential, and serum and plasma for storage. For family members with diabetes, blood will also be tested for A1c.

Locations (1)

Medical College of Wisconsin
Milwaukee, Wisconsin, United States