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RECRUITINGPhase 4INTERVENTIONAL

Vitamin D Homeostasis in Sarcoidosis

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study evaluates the relationship between vitamin-D status and severity of sarcoidosis, and the effects of vitamin-D repletion in vitamin-D insufficient patients with sarcoidosis. Half the patients with sarcoidosis who are vitamin-D insufficient will receive standard vitamin-D supplementation via standard regimen while the other half will receive a placebo. Sarcoidosis patients who are vitamin-D sufficient will also act as controls.

Who May Be Eligible (Plain English)

Who May Qualify: - Stable medical condition defined as no hospitalization or emergency room visit in the previous 3 months - No evidence of active pulmonary or systemic infection - No other active inflammatory disease, - No active malignancy. - Normal serum ionized calcium level Who Should NOT Join This Trial: - Hospitalization or emergency room visit in the previous 3 months - Evidence of active pulmonary or systemic infection - Evidence of active other inflammatory disease - Evidence of active malignancy - Elevated serum ionized calcium level Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Stable medical condition defined as no hospitalization or emergency room visit in the previous 3 months * No evidence of active pulmonary or systemic infection * No other active inflammatory disease, * No active malignancy. * Normal serum ionized calcium level Exclusion Criteria: * Hospitalization or emergency room visit in the previous 3 months * Evidence of active pulmonary or systemic infection * Evidence of active other inflammatory disease * Evidence of active malignancy * Elevated serum ionized calcium level

Treatments Being Tested

DRUG

Ergocalciferol

Vitamin D2 50,000 units

DRUG

Placebo

Sugar pill manufactured to mimic ergocalciferol 50,000 units

DRUG

Calcium Citrate with Vitamin D2

To meet the recommended minimum daily dietary requirements

Locations (1)

University of Texas Southwestern Medical Center, and Parkland Health and Hospital System
Dallas, Texas, United States