RECRUITINGOBSERVATIONAL

Retinal Imaging in Neurodegenerative Disease

Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study

About This Trial

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.

Who May Be Eligible (Plain English)

Who May Qualify: - Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome) - Adults without neurodegenerative disease Who Should NOT Join This Trial: - Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition. - Eyes that have had intraocular surgery, other than cataract surgery. If two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome) * Adults without neurodegenerative disease Exclusion Criteria: * Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition. * Eyes that have had intraocular surgery, other than cataract surgery. If two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study.