Mesenchymal Stromal Cells as Treatment for Digital Ulcers in Systemic Sclerosis

Who May Qualify: - Established diagnosis of SSc according to the 2013 ACR/EULAR criteria - At least one active digital ulcer (painful area, \>2 mm in diameter with visible depth and loss of dermis) refractory to intravenous prostacyclins - 'Refractory to prostacyclins' is defined as - Worsening of ulcer(s) within 1 month after prostacyclins iv - No improvement of ulcer(s) after 2 months after prostacyclins iv, as judged by the referring physician - Recurrence of exactly the same ulcer(s) (same location) within 3 months after prostacyclins iv - Written willing to sign a consent form Who Should NOT Join This Trial: - Ulcer with underlying calcinosis (ruled out by X-ray prior to screening/inclusion) - History of neoplasm or malignancy in the past 10 years - Pregnancy or unwillingness to use adequate contraception during study - Serious known concomitant disease with life expectancy \<1 year - Uncontrolled hypertension - Uncontrolled acute or chronic infection with systemic symptoms (e.g. fever) - Follow-up impossible Always talk to your doctor about whether this trial is right for you.