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RECRUITINGOBSERVATIONAL

Cardiovascular Risk and Chronic Obstructive Pulmonary Disease

Cardiovascular Risk and Chronic Obstructive Pulmonary Disease (COPD)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The principal objective of the study is to measure parameters of inflammation, oxidative stress, and vascular, respiratory, and peripheral muscle function parameters, and identify parameters indicative of evolving cardiovascular risk (CVR) in COPD patients, using multivariate analysis.

Who May Be Eligible (Plain English)

Who May Qualify: For patients with stable COPD: - Men or women aged 18 to 85 - FEV1/FVC \< 70% or proven BPCO - Patients who have given their free and willing to sign a consent form in writing For patients with decompensated COPD: - Men or women aged 18 to 85 - FEV1/FVC \< 70% or proven BPCO - At the time of acute respiratory failure (ARF), when admitted to hospital: - Respiratory rate \> 25 cycles per minute - PaCO2 \> 45 mmHg - blood pH \< 7.35 - When included in the study: - pH \> 7.33 at the end of ARF, 2 days in a row, or 3 to 7 days post-D1 decompensation (admission to the hospital) - Fever \< 38.5°C - Patients who have given their free and willing to sign a consent form in writing Who Should NOT Join This Trial: - Obvious evolving infection or CRP \> 100 mg/L - Cardiac decompensation considered the main cause of decompensation or chronic heart failure with LVEF \< 45% - Evolving neoplasia - On antioxidants: N-acetyl-cysteine, selenium, vit. C, vit. E - Pregnant or nursing women - Patients under tutorship or curatorship - Patients participating in a drug clinical research study - Patients not affiliated to the French social security system (or equivalent) - Patients deprived of liberty or hospitalized without consent. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: For patients with stable COPD: * Men or women aged 18 to 85 * FEV1/FVC \< 70% or proven BPCO * Patients who have given their free and informed consent in writing For patients with decompensated COPD: * Men or women aged 18 to 85 * FEV1/FVC \< 70% or proven BPCO * At the time of acute respiratory failure (ARF), when admitted to hospital: * Respiratory rate \> 25 cycles per minute * PaCO2 \> 45 mmHg * blood pH \< 7.35 * When included in the study: * pH \> 7.33 at the end of ARF, 2 days in a row, or 3 to 7 days post-D1 decompensation (admission to the hospital) * Fever \< 38.5°C * Patients who have given their free and informed consent in writing Exclusion Criteria: * Obvious evolving infection or CRP \> 100 mg/L * Cardiac decompensation considered the main cause of decompensation or chronic heart failure with LVEF \< 45% * Evolving neoplasia * On antioxidants: N-acetyl-cysteine, selenium, vit. C, vit. E * Pregnant or nursing women * Patients under tutorship or curatorship * Patients participating in a drug clinical research study * Patients not affiliated to the French social security system (or equivalent) * Patients deprived of liberty or hospitalized without consent.

Locations (1)

University Grenoble Hospital
Grenoble, La Tronche, France