RECRUITINGOBSERVATIONAL
Safety and Durability of Sirolimus for Treatment of LAM
Multicenter International Durability and Safety of Sirolimus in LAM Trial (MIDAS)
About This Trial
The MIDAS study aims to follow male and female LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of their clinical care. Adult female TSC patients may also enroll, with or without lung cysts.
Who May Be Eligible (Plain English)
Who May Qualify:
- Female or male, age 18 or over
- Diagnosis of LAM based on ATS/JRS criteria
- Signed and dated willing to sign a consent form
- On chronic therapy, newly treated or may be considered for therapy with mTOR inhibitors or previously intolerant of or having failed mTOR inhibitor therapy
Who Should NOT Join This Trial:
- Inability to attend at least one RLD Clinic visit per year
- Inability to give willing to sign a consent form
- Inability or unwillingness to perform pulmonary function testing
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Female or male, age 18 or over
* Diagnosis of LAM based on ATS/JRS criteria
* Signed and dated informed consent
* On chronic therapy, newly treated or may be considered for therapy with mTOR inhibitors or previously intolerant of or having failed mTOR inhibitor therapy
Exclusion Criteria:
* Inability to attend at least one RLD Clinic visit per year
* Inability to give informed consent
* Inability or unwillingness to perform pulmonary function testing
Treatments Being Tested
DRUG
Sirolimus
Sirolimus treatment will be part of a participant's clinical care and will be managed by their physician.
DRUG
Everolimus
Everolimus treatment will be part of a participant's clinical care and will be managed by their physician.
Locations (20)
Stanford University Medical Center
Stanford, California, United States
National Jewish Health
Denver, Colorado, United States
Mayo Clinic Jacksonville
Jacksonville, Florida, United States
Emory University School of Medicine
Atlanta, Georgia, United States
Loyola University Medical Center, Chicago
Maywood, Illinois, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Mayo Clinic Rochester
Rochester, Minnesota, United States
Washington University School of Medicine
St Louis, Missouri, United States
University of Rochester Medical Center
Rochester, New York, United States
University of Cincinnati
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
Oregon Health and Science University
Portland, Oregon, United States
University of Pennsylvania Medical Center
Philadelphia, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
University of Texas Southwestern Medical Center
Dallas, Texas, United States
University of Texas Health Center
Houston, Texas, United States
University of Utah School of Medicine
Salt Lake City, Utah, United States
Swedish Medical Center
Seattle, Washington, United States