Deep Brain Stimulation (DBS) for Obsessive Compulsive Disorder (OCD): Improving Targeting Precision

Who May Qualify: - Diagnosis of OCD following the diagnostic and statistical manual of mental disorders-fourth edition (DSM-IV) criteria for OCD (300.3). - Failure of documented trials of pharmacotherapy, following an appropriate treatment algorithm for OCD. - Failure of documented trial of cognitive and behavioural therapy - Duration of illness: min. 5 year - Y-BOCS (Yale-Brown Obsessive Compulsive Scale) at least 30/40. - Age: 20-65 year Who Should NOT Join This Trial: - DSM-IV diagnosis on axis 2 of severe personality disorder in cluster A or B, especially in the case of heightened risk for acting-out behavior. - DSM-IV diagnosis on axis 3 of organic brain pathology or significant abnormalities on MRI. - Present or past history of psychotic symptoms. - Present substance abuse, or instable remission of substance abuses (i.e. no substance abuse during the last 12 months). - Any disorder affecting cognitive functioning, other than motor tics and Gilles de la Tourette's Syndrome - Mental retardation. A minimum threshold of cognitive skills is needed for adequate reporting on questionnaires and evaluation, and for technical handling of the instruments in a later faze. Always talk to your doctor about whether this trial is right for you.