RECRUITINGINTERVENTIONAL
Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)
Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI.
About This Trial
Eligible patients with high risk colorectal malignancy (T3/4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery six monthly for three years. Findings of liver MRIs as reported by radiology PI will be shared with their local MDT who make decisions as appropriate, including the management of any identified liver metastases, according to local protocol.
Who May Be Eligible (Plain English)
Who May Qualify:
1. Have a high risk primary colorectal malignancy
2. Have a negative CT or includes no confirmatory evidence of liver metastases
3. Is able to undergo treatment if liver metastasis is found
4. Have provided written willing to sign a consent form to participate in the study
5. Be aged 16 years or over
Who Should NOT Join This Trial:
1. Have had a previous colorectal malignancy
2. Have metastatic disease
3. Have a synchronous second malignancy
4. Are contraindicated for MRI
5. Has a T3b or below low rectal tumour without EMVI or N1c
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
1. Have a high risk primary colorectal malignancy
2. Have a negative CT or includes no confirmatory evidence of liver metastases
3. Is able to undergo treatment if liver metastasis is found
4. Have provided written informed consent to participate in the study
5. Be aged 16 years or over
Exclusion Criteria:
1. Have had a previous colorectal malignancy
2. Have metastatic disease
3. Have a synchronous second malignancy
4. Are contraindicated for MRI
5. Has a T3b or below low rectal tumour without EMVI or N1c
Treatments Being Tested
OTHER
Diffusion Weighted MRI scan
Liver metastases found on the additional DW-MRI scans will be discussed at MDT and treated according to local site policy.
Locations (13)
Macclesfield District General Hospital
Macclesfield, Cheshire, United Kingdom
Queen's Hospital
Burton-on-Trent, Derbyshire, United Kingdom
Broomfield Hospital
Chelmsford, Essex, United Kingdom
Royal Bolton Hospital
Bolton, Greater Manchester, United Kingdom
Medway Maritime Hospital
Gillingham, Kent, United Kingdom
University Hospital of South Manchester & Manchester Royal Infirmary
Wythenshawe, Manchester, United Kingdom
Royal Liverpool Hospital
Liverpool, Merseyside, United Kingdom
Royal Stoke University Hospital
Stoke-on-Trent, Staffordshire, United Kingdom
Royal Marsden Hospital
Sutton, Surrey, United Kingdom
Royal Gwent Hospital
Newport, Wales, United Kingdom
George Eliot Hospital
Nuneaton, Warwickshire, United Kingdom
Salisbury District Hospital
Salisbury, Wiltshire, United Kingdom
Queen Alexandra Hospital
Portsmouth, United Kingdom