Stereotactic Body Radiation Therapy (SBRT) for Unresectable Liver Metastases

Who May Qualify: - Karnofsky Performance Scale (KPS) equal or greater than 70 - 1 to 4 liver metastases with an individual maximum diameter of up to 5 cm - Lesions considered unresectable or patients considered unfit for surgery - Histology of the primary tumor: colorectal adenocarcinoma, carcinoma of the anal canal or gastrointestinal neuroendocrine tumors. - Absence of evidence of extra-hepatic disease or extra-hepatic disease to be treated with curative intent. - Minimum interval of 2 weeks between systemic chemotherapy and SBRT. - Adequate bone marrow function defined as: - absolute neutrophils count \> 1,800 cells / mm 3 - platelets \> 100,000 cells / mm 3 - hemoglobin \> 8.0 g / dl ( transfusion or other intervention accepted) Who Should NOT Join This Trial: - Concomitant chemotherapy - Prior radiotherapy to the upper abdomen - Pregnancy - Underlying Cirrhosis - Active hepatitis or clinically significant liver failure - Prior invasive neoplasm except for non-melanoma skin cancer, or unless more than five years without evidence of disease - Severe Comorbidity - Current anticoagulant treatment Always talk to your doctor about whether this trial is right for you.