RECRUITINGOBSERVATIONAL

Assessment of Eloquent Function in Brain Tumor Patients

Assessment of Reorganization and Plasticity of Eloquent Function in Patients With Brain Tumors

About This Trial

Purpose of the study: AIM 1: Prospectively collect pre-operative \[functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), magnetoencephalography (MEG)\] and intra-operative mapping data in patients with intra-axial brain tumors to assess how well each modality predicts the location of eloquent brain function. In addition, each modality will be compared with the other. AIM 2: Assess reorganization of eloquent brain function and plasticity in patients with intra-axial brain tumors. This will be accomplished by prospectively collecting post-operative mapping studies and neuropsychological tests to compare them to prior mapping studies as stated above.

Who May Be Eligible (Plain English)

Who May Qualify: - 19 years and older - Brain tumor in or near eloquent brain regions that is appropriate for attempted resection - Appropriate body habitus and mental status/capacity to participate with non-invasive or invasive mapping - Benign or malignant intra-axial brain tumor - Primary or metastatic intra-axial brain tumor Who Should NOT Join This Trial: - Any contraindication to MRI (i.e. implanted devices) - Inappropriate body habitus or mental status/capacity to participate with non-invasive or invasive mapping in a safe and reliable manner - Declining to participate - Lacks capacity to understand the study or consent for themselves - Neurologic status which precludes testing (poor function- not testable) - Positive pregnancy test - End stage renal disease or severe renal dysfunction Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * 19 years and older * Brain tumor in or near eloquent brain regions that is appropriate for attempted resection * Appropriate body habitus and mental status/capacity to participate with non-invasive or invasive mapping * Benign or malignant intra-axial brain tumor * Primary or metastatic intra-axial brain tumor Exclusion Criteria: * Any contraindication to MRI (i.e. implanted devices) * Inappropriate body habitus or mental status/capacity to participate with non-invasive or invasive mapping in a safe and reliable manner * Declining to participate * Lacks capacity to understand the study or consent for themselves * Neurologic status which precludes testing (poor function- not testable) * Positive pregnancy test * End stage renal disease or severe renal dysfunction

Treatments Being Tested

DIAGNOSTIC_TEST

Brain mapping

Brain mapping will be employed pre-, intra-, and post-operatively to evaluate specific functions.

Locations (1)

University of Nebraska Medical Center

Omaha, Nebraska, United States