RECRUITINGOBSERVATIONAL
Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study
Genetic Epidemiology of Severe, Early-Onset Chronic Obstructive Pulmonary Disease
About This Trial
Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility. The purpose of this study is to identify genetic factors that predispose some individuals to develop COPD.
Who May Be Eligible (Plain English)
Inclusion Criteria for Early-Onset COPD Probands:
- Early onset of COPD in individuals younger than 53 years old
- Spirometry results that are indicative of severe COPD (FEV1 \< 40% predicted)
- Physician-diagnosed COPD
Exclusion Criteria for Early-Onset COPD Probands:
- Severe alpha-1 antitrypsin deficiency
- Other chronic lung diseases in participants with COPD (except asthma)
- Pregnant
- Any previous lung surgery including lung transplant or lung reduction volume surgery (LVRS); unless prior Pulmonary Function Tests are available
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria for Early-Onset COPD Probands:
* Early onset of COPD in individuals younger than 53 years old
* Spirometry results that are indicative of severe COPD (FEV1 \< 40% predicted)
* Physician-diagnosed COPD
Exclusion Criteria for Early-Onset COPD Probands:
* Severe alpha-1 antitrypsin deficiency
* Other chronic lung diseases in participants with COPD (except asthma)
* Pregnant
* Any previous lung surgery including lung transplant or lung reduction volume surgery (LVRS); unless prior Pulmonary Function Tests are available
Locations (1)
Brigham and Women's Hospital
Boston, Massachusetts, United States