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Bristol-Myers Squibb

26 clinical trials · 26 recruiting · INDUSTRY

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

Trials by Bristol-Myers Squibb

RECRUITINGPhase 2 / Phase 3NCT07063745

A Study to Compare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab...

The purpose of this study is to compare the clinical benefit of the combination of BMS-986504 (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy...

Sponsor: Bristol-Myers SquibbEnrolling: 59020 locations
Metastatic Non-small Cell Lung Cancer With MTAP Deletion
RECRUITINGPhase 3NCT06561386

A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for...

The purpose of this study is to compare the efficacy of Nivolumab and Relatlimab in combination with chemotherapy to Pembrolizumab with Chemotherapy in participants with stage IV...

Sponsor: Bristol-Myers SquibbEnrolling: 100020 locations
Non-small Cell Lung Cancer
RECRUITINGPhase 1NCT07195682

A First-in-Human Study of BMS-986506 in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC)

This is a first-in-human study of BMS-986506 in participants with advanced Clear Cell Renal Cell Carcinoma (ccRCC). The primary objective of this study is to find out if...

Sponsor: Bristol-Myers SquibbEnrolling: 1259 locations
Renal Cell Carcinoma
RECRUITINGPhase 2 / Phase 3NCT07221149

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in...

The purpose of this study is to evaluate the safety and efficacy of Pumitamig in combination with chemotherapy versus Nivolumab in combination with chemotherapy in participants...

Sponsor: Bristol-Myers SquibbEnrolling: 69020 locations
Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma
RECRUITINGPhase 1 / Phase 2NCT06730750

A Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors

This is a study of BMS-986490 as a monotherapy and in combination with bevacizumab in participants with select advanced solid tumors known to express CEACAM5.

Sponsor: Bristol-Myers SquibbEnrolling: 3606 locations
Advanced Solid Tumors
RECRUITINGPhase 1NCT05245500

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

This is a Phase 1, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable or metastatic solid...

Sponsor: Bristol-Myers SquibbEnrolling: 33620 locations
MesotheliomaNon Small Cell Lung CancerMalignant Peripheral Nerve Sheath Tumors+3
RECRUITINGPhase 3NCT07011745

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With...

The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease.

Sponsor: Bristol-Myers SquibbEnrolling: 35220 locations
Alzheimer Disease
RECRUITINGNCT05170126

A Study on the Safety of Ozanimod Exposure in Pregnant Women and Their Offspring

The purpose of this study is to provide information on maternal, fetal, and infant outcomes following exposure of ozanimod during pregnancy so that participants and physicians can...

Sponsor: Bristol-Myers SquibbEnrolling: 11823 locations
Multiple Sclerosis
RECRUITINGNCT06146660

A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy

The purpose of this observational post-marketing surveillance study is to assess the real-world safety of mavacamten for the treatment of symptomatic obstructive hypertrophic...

Sponsor: Bristol-Myers SquibbEnrolling: 6002 locations
Obstructive Hypertrophic Cardiomyopathy
RECRUITINGNCT07361289

A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic...

The purpose of this study is to assess the effectiveness of mavacamten treatment in Chinese adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM) in real-world...

Sponsor: Bristol-Myers SquibbEnrolling: 50015 locations
Hypertrophic Cardiomyopathy
RECRUITINGNCT05939700

Mavacamten Pregnancy Surveillance Program

The purpose of this observational pregnancy safety study is to assess maternal, fetal, and infant outcomes after exposure to mavacamten at any time during pregnancy and/or...

Sponsor: Bristol-Myers SquibbEnrolling: 201 location
BreastfeedingHypertrophic CardiomyopathyPregnancy Related
RECRUITINGNCT07383025

Mavacamten Post-marketing Surveillance in Patients With Obstructive Hypertrophic Cardiomyopathy in Japan

The purpose of this study is to assess the real-world effectiveness and safety of mavacamten in patients with obstructive hypertrophic cardiomyopathy (HCM) receiving mavacamten in...

Sponsor: Bristol-Myers SquibbEnrolling: 2001 location
Obstructive Hypertrophic Cardiomyopathy (oHCM)
RECRUITINGPhase 3NCT07140913

A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed...

The purpose of this study is to evaluate the efficacy and safety of adjunctive KarXT for the treatment of mania in participants with Bipolar-I Disorder.

Sponsor: Bristol-Myers SquibbEnrolling: 42420 locations
ManiaBipolar Disorder
RECRUITINGPhase 3NCT06929273

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

This is a phase 3, open-label extension study to assess the long-term safety of KarXT for the treatment of mania or mania with mixed features in Bipolar-I disorder (BP-I) The...

Sponsor: Bristol-Myers SquibbEnrolling: 45020 locations
Bipolar Disorder Type I With Mania
RECRUITINGPhase 3NCT06882785

A Study to Evaluate the Efficacy and Safety of KarXT in Acutely Psychotic Japanese Adult Participants With Schizophrenia

The purpose of this study is to evaluate the efficacy and safety of KarXT in acutely psychotic Japanese adult participants with schizophrenia

Sponsor: Bristol-Myers SquibbEnrolling: 25020 locations
Schizophrenia
RECRUITINGPhase 2 / Phase 3NCT05076175

A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative...

The purpose of this study is to evaluate the effectiveness and safety of ozanimod (RPC1063) in achieving and maintaining clinical remission. Ozanimod will be administered orally...

Sponsor: Bristol-Myers SquibbEnrolling: 12020 locations
Colitis, Ulcerative
RECRUITINGNCT06073873

A Post-Marketing Surveillance Study to Assess Safety of Ozanimod in Patients With Moderate to Severe Active UC in Korea

The purpose of this observational study is to assess the real-world safety of ozanimod in Korean participants with moderate to severe active ulcerative colitis.

Sponsor: Bristol-Myers SquibbEnrolling: 30001 location
Ulcerative Colitis
RECRUITINGNCT06258668

Real-World Safety and Effectiveness of Sotyktu (Deucravacitinib) in Patients With Moderate-to-Severe Plaque Psoriasis...

The purpose of this observational study is to describe the safety and effectiveness of deucravacitinib in participants in Korea that have been diagnosed with moderate-to-severe...

Sponsor: Bristol-Myers SquibbEnrolling: 5052 locations
Moderate-to-severe Plaque Psoriasis
RECRUITINGNCT06382987

A Study of the Comparative Effectiveness of Deucravacitinib in Adults With Plaque Psoriasis in Japan (RePhlect)

This is a prospective, observational, real-world study of adult participants in Japan with physician-reported diagnosis of plaque psoriasis treated with deucravacitinib or...

Sponsor: Bristol-Myers SquibbEnrolling: 6002 locations
Plaque Psoriasis
RECRUITINGPhase 3NCT06979453

A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants...

The purpose of this study is to evaluate the efficacy, safety, and drug levels of Deucravacitinib (BMS-986165) in adolescent participants with moderate to severe plaque psoriasis

Sponsor: Bristol-Myers SquibbEnrolling: 36620 locations
Plaque Psoriasis
RECRUITINGPhase 3NCT04772079

A Study to Evaluate the Drug Levels, Efficacy and Safety of Deucravacitinib in Pediatric Participants With Moderate to...

The purpose of this pediatric study is to evaluate the drug levels, efficacy and safety of Deucravacitinib in pediatric participants aged 4 to \<18 years with moderate to severe...

Sponsor: Bristol-Myers SquibbEnrolling: 15320 locations
Plaque Psoriasis
RECRUITINGPhase 3NCT07116967

Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)

A study to evaluate the long-term safety of Deucravacitinib versus Ustekinumab in participants with psoriasis

Sponsor: Bristol-Myers SquibbEnrolling: 304020 locations
Plaque Psoriasis
RECRUITINGNCT07017699

A Study to Assess Deucravacitinib Safety in Pregnancy

The purpose of this study is to assess pregnancy and infant outcomes among pregnant participants enrolled in an established North American pregnancy registry (Organization of...

Sponsor: Bristol-Myers SquibbEnrolling: 9001 location
Psoriasis (PsO)
RECRUITINGNCT05744466

A Real-world Observational Study to Compare Effectiveness of Deucravacitinib Vs Apremilast in Adults With Plaque...

The purpose of this study is to understand the comparative effectiveness of deucravacitinib versus apremilast in adults with plaque psoriasis.

Sponsor: Bristol-Myers SquibbEnrolling: 15001 location
Psoriasis
RECRUITINGNCT06512337

A Observational Study to Evaluate Deucravacitinib in Patients With Moderate Plaque Psoriasis in China

The purpose of this study is to collect and evaluate real-world data on the effectiveness of deucravacitinib treatment in adults with moderate plaque psoriasis in China.

Sponsor: Bristol-Myers SquibbEnrolling: 1505 locations
Plaque Psoriasis
RECRUITINGNCT06701513

A Real-world Study to Evaluate the Effectiveness of Deucravacitinib in Adults With Plaque Psoriasis in France (RePhlect)

The purpose of this study is to assess the real-world effectiveness of deucravacitinib treatment in adults diagnosed with moderate-to-severe plaque psoriasis

Sponsor: Bristol-Myers SquibbEnrolling: 35020 locations
Psoriasis